A new study recently published in Cell Metabolism has shown how running produces an increase in circulating levels of a protein known as cathepsin B, which has been linked to improved memory and spatial learning.
A team of neuroscientist from the National Institute on Aging in the United States, the Otto-von-Guericke University, and the German Center for Neurodegenerative Diseases, found that when cathepsin B was applied to brain cells, it spurred the production of molecules related to neurogenesis – the growth and development of nervous system tissue, including brain cells. The research team also produced evidence from the study that “cathepsin B is up-regulated in blood by exercise for three species–mice, Rhesus monkeys, and humans. Moreover, in humans who exercise consistently for four months, better performance on complex recall tasks, such as drawing from memory, is correlated with increased cathepsin B levels.” Other studies have found that cathepsin B is also neuro-protective and can clear amyloid plaques, which crate a sticky buildup on the outside of neurons and can be toxic to neurons in the brain.
Source: Healthy Nutrimania